Thermal Response of Dielectric Nanoparticle-Infused Tissue Phantoms During Microwave-Assisted Hyperthermia

نویسندگان

چکیده

Abstract Hyperthermia has been in use for many years, as a potential alternative modality cancer treatment. In this paper, an experimental investigation of microwave-assisted thermal heating (MWATH) tissue phantom using domestic microwave oven reported. Computer simulations finite element method-based tools were also carried out to support the observations and probe insight into transport aspects deep within phantom. A good agreement between predicted measured temperature was achieved. Furthermore, experiments conducted investigate efficacy dielectric nanoparticles, namely, alumina (Al2O3) titanium oxide (TiO2) during MWATH nanoparticle-infused tumor phantoms. deep-seated injected with nanoparticle solution specifically mimicked experiments. Interesting results obtained terms spatiotemporal history An elevation distribution achieved vicinity targeted zone due presence spatial grossly morphed. We conclusively show, that unlike other nanoparticle-mediated hyperthermia techniques, direct injection nanoparticles leads enhanced heat generation neighboring healthy tissues. The inhomogeneity event is evident from local occurrence hot spots cold spots, respectively. present findings may have far-reaching implications framework predicting distributions ablation (MWA).

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ژورنال

عنوان ژورنال: Journal of Thermal Science and Engineering Applications

سال: 2021

ISSN: ['1948-5085', '1948-5093']

DOI: https://doi.org/10.1115/1.4050665